A new rat model of the human serial reaction time task: contrasting effects of caudate and hippocampal lesions.

نویسندگان

  • Michael A Christie
  • John C Dalrymple-Alford
چکیده

There is often little correspondence between human and animal examples of nondeclarative memory. The serial reaction time task (SRT) is a sequence learning example of human nondeclarative memory that may be suitable for development as an animal model. The SRT is believed to be impaired by basal ganglia, not limbic system damage, but there is uncertainty whether limbic system pathology does in fact leave the SRT unimpaired. We therefore developed a new rat model that closely approximated the human SRT, using intracranial self-stimulation to promote rapid continuous responding to four adjacent nose pokes in a single test session. Intact rats that experienced repeated sequences demonstrated robust interference effects when switched to a random sequence of cued responses (at 4-, 8-, and 12-sequence lengths), unlike intact controls that experienced the random sequences only. The interference effect in the human task is a key measure for nondeclarative sequence learning. Rats with dorsal caudate lesions that experienced massed sequence repetitions showed an interference effect at the four-sequence length only. By contrast, rats with dorsal hippocampal lesions showed an interference effect at all sequence lengths. This new rat SRT model clarifies the basal ganglia-limbic system dichotomy suggested by human work.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Predicting Normal People’s Reaction Time based on Hippocampal Local Efficiency During a Memory-Guided Attention Task

Background: There are some convincing shreds of evidence indicating that memory can direct attention. The local efficiency of an area in the brain, as a quantitative feature in a complex network, indicates how the surrounding nodes can transfer the information when a specific node is omitted. This feature is a scale for measuring efficient integration of information in the brain. Objectives:...

متن کامل

Implicit Motor Learning after Unilateral Stroke Using Serial Reaction Time Task

Introduction: Motor skills and learning after stroke are of a great importance. This study aimed at studying implicit learning in unilateral stroke patients using affected hand and comparison with normal subjects. Methods: A serial reaction time task by using a software was applied for studying implicit motor learning in 15 stroke patients and 15 matched normal subjects. In this task 4 squar...

متن کامل

Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neuron of the CA1 Hippocampus in Rat Model of Alzheimer\'s Disease

Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region of a rat model of AD. Methods: In the current experimental study, adult male Wistar rats were randomly divided into four groups: Nucleus Basal...

متن کامل

Contrasting effects on discrimination learning after hippocampal lesions and conjoint hippocampal-caudate lesions in monkeys.

Eighteen monkeys with lesions of the hippocampal region (the hippocampus proper, the dentate gyrus, and the subiculum) made by an ischemic procedure, radio frequency, or ibotenic acid were tested on a simple, two-choice object discrimination learning task that has been shown to be sensitive to large lesions of the medial temporal lobe. The monkeys were also tested on two other discrimination ta...

متن کامل

A double dissociation within striatum between serial reaction time and radial maze delayed nonmatching performance in rats.

Lesions involving the intralaminar thalamic nuclei have been associated with impairments in working memory and intentional motor function in human clinical cases and animal models of amnesia. The intralaminar nuclei have afferent and efferent connections related to striatum. To test whether disruption of striatal function can account for impairments produced by intralaminar lesions, we investig...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of neuroscience : the official journal of the Society for Neuroscience

دوره 24 5  شماره 

صفحات  -

تاریخ انتشار 2004